Blar i forfatter "Kjær, Mette"

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    • Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: A laboratory study using an in vitro model 

      Eksteen, Mariana; Heide, Gøril; Tiller, Heidi; Zhou, Yan; Nedberg, Nora Hersoug; Martinez-Zubiaurre, Inigo; Husebekk, Anne; Skogen, Bjørn Ragnar; Stuge, Tor Brynjar; Kjær, Mette (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-21)
      Background: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a bleeding disorder caused by maternal antibodies against paternal human platelet antigens (HPAs) on fetal platelets. Antibodies against HPA-1a are accountable for the majority of FNAIT cases. We have previously shown that high levels of maternal anti-HPA-1a antibodies are associated with clinically significant reduced birth ...

    • A combined effect of anti-HPA-1a and anti-HLA Class I in pregnancy? 

      Dahl, Jesper; Skogen, Bjørn; Kjær, Mette; Husebekk, Anne; Kjeldsen-Kragh, Jens; Tiller, Heidi (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)
      <i>Background</i> - Maternal anti–human leukocyte antigen (HLA) Class I is commonly detected alongside anti–human platelet antigen (HPA)-1a in fetal and neonatal alloimmune thrombocytopenia (FNAIT). Little is known regarding whether the presence of anti-HLA Class I may exert an additive effect on the risk and severity of FNAIT.<br><br> <i>Methods and Materials</i> - We reanalyzed samples originally ...

    • Environmental pollutants in blood donors: The multicentre Norwegian donor study 

      Averina, Maria; Hervig, Tor; Huber, Sandra; Kjær, Mette; Kristoffersen, Einar Klæboe; Bolann, Bjørn Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-11)
      <i>Objectives</i> - The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions.<br><br> <i>Background</i> - Transfused blood may be a potential source of exposure to heavy metals and organic pollutants and presents a risk to vulnerable patient groups such as premature infants.<b ...

    • Fetal exposure to maternal human platelet antigen-1a does not induce tolerance. An analytical observational study 

      Kjær, Mette; Tiller, Heidi; Heide, Gøril; Kjeldsen-Kragh, Jens; Skogen, Bjørn Ragnar; Husebekk, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-24)
      Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a disease that may cause severe bleeding complications with risk of perinatal death or lifelong disability. The main cause of FNAIT is maternal antibodies against human platelet antigen (HPA)-1a. Both fetomaternal bleeding and transplacental trafficking of fetal cells during pregnancy could be the cause of alloimmunization. Persistence of ...

    • Fetal/neonatal alloimmune thrombocytopenia: A systematic review of impact of HLA-DRB3∗01:01 on fetal/neonatal outcome 

      Kjeldsen-Kragh, Jens; Fergusson, Dean; Kjær, Mette; Lieberman, Lani; Greinacher, Andreas; Murphy, Michael F.; Bussel, James B.; Bakchoul, Tamam; Corke, Stacy; Bertrand, Gerald; Oepkes, Dick; Baker, Jillian M.; Hume, Heather; Massey, Edwin; Kaplan, Cecile; Arnold, Donald M.; Baidya, Shoma; Ryan, Greg; Savoia, Helen; Landry, Denise; Shehata, Nadine (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-27)
      The most common, severe cases of fetal and neonatal alloimmune thrombocytopenia among whites are caused by antibodies against human platelet antigen 1a (HPA-1a). The aims of this systematic review and meta-analysis are to determine the association between maternal HLA-DRB3*01:01 and: (1) HPA-1a-alloimmunization and (2) neonatal outcome in children born of HPA-1a-immunized women. A systematic ...

    • An HPA-1a-positive platelet-depleting agent for prevention of fetal and neonatal alloimmune thrombocytopenia: a randomized, single-blind, placebo-controlled, single-center, phase 1/2 proof-of-concept study 

      Geisen, Christof; Kjær, Mette; Fleck, Erika; Skogen, Bjørn; Armstrong, Roisin; Behrens, Frank; Bhagwagar, Zubin; Braeuninger, Susanne; Mörtberg, Anette; Olsen, Klaus Juel; Scafer, Stephan Martin Gaston; Walter, Carmen; Seifried, Erhard; Wikman, Agneta; Kjeldsen-Kragh, Jens; Koehm, Michaela (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-22)
      Background: Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a rare and potentially life-threatening bleeding disorder of the fetus/newborn. Antibodies against human platelet antigen 1a (HPA-1a) are associated with the most frequent FNAIT cases. There are no approved therapies for FNAIT prevention or treatment. RLYB211 is a polyclonal HPA-1a hyperimmune IgG being developed to prevent ...

    • Our health, our research. Identifying public health research priorities among children and youth in a multiethnic population: Protocol for a community-based participatory health research priority survey 

      Irgens, Eirik Lind; Berglen, Gunnhild; Christoffersen, Tore; Henninen, Anita Pettersen; Hermansen, Rune Hermann; Karlsen, Maret Risten Eira; Kokkvoll, Ane Sofie; Liabo, Kristin; Møllersen, Snefrid; Rugland, Grete; Stock, Magnhild Helen; Zachariassen, Tonje Olsen; Kjær, Mette (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-19)
      Introduction Emphasis on public involvement (PI) in health research has increased in the last 20 years. However, there is limited literature on PI in planning and conducting population-based health research. This study aims to identify child and adolescent health research priorities among children and stakeholder groups in Northern Norway by inviting PI groups to collaborate with researchers ...

    • Strategies to develop a prophylaxis for the prevention of HPA-1a immunization and fetal and neonatal alloimmune thrombocytopenia 

      Kjær, Mette; Geisen, Christof; Akkøk, Cigdem Ahaein; Wikman, Agneta; Sachs, Ulrich; Bussel, James B.; Nielsen, Kaspar; Walles, Katarina; Curtis, Brian R.; Vidarsson, Gestur; Järås, Kerstin; Skogen, Bjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-31)
      Anti-HPA-1a-antibodies are the main cause of fetal and neonatal alloimmune thrombocytopenia (FNAIT) which may result in intracranial hemorrhage (ICH) and death among fetuses and newborns. Advances in understanding the pathogenesis of FNAIT and proof of concept for prophylaxis to prevent immunization suggest that development of hyperimmune anti-HPA-1a IgG aimed at preventing immunization against ...